刘浩然（1975-），博士，助理教授，E-Mail: tom8833@hnu.edu.cn 。2006年毕业于中国药科大学，获药理学博士学位。同年7月进入湖南大学化学化工学院工作。
    教学：目前主讲本科生选修课《药理学》及《药物分析》、通识选修课《生活中的药学》、研究生学位专业课《分子药理学》，带教化学专业实验课。主持编写创新性药学方向专业实验课讲义一本。曾主讲《药剂学》、《药物动力学》及《化学与健康》选修课程。2013年获湖南大学“我心目中最敬爱的老师”称号。2015年获校级教学改革成果二等奖。
   
    科研：主要从事天然产物结构修饰及其生物活性研究，在酶抑制剂的研究方面具有较丰富的经验。参与国家自然基金项目两项，主持省自然基金及省科技计划各一项，主持校级、省级教改课题多项。主编教材一部。发表论文三十余篇。
   
    目前研究方向或兴趣：
    (1) 以天然产物为先导化合物的酶抑制剂的研究
    (2) 酶抑制剂体内分析及亲和色谱　
   （3）透皮吸收制剂的研究
   （4）中草药成份分析及保健饮品开发

    近斯发表的部分论文：
    1 Liu HR, Liu LB, Gao XH, Liu YZ*, Xu WJ，He W,Jiang H， Tang JJ, Fan HQ, Xia XH.Novel ferulic amide derivatives with tertiary amine side chain as
      acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group.European Journal of Medicinal Chemistry,2017,126:810-822.
    2 Liu HR*, Fan HQ, Gao XH, Huang XQ, Liu XJ,Liu LB, Zhou C, Tang JJ, Wang QA,Liu WK. Design, synthesis and preliminary structure–activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives. J Enzyme Inhib Med Chem. 2016，31(4):580-589.  
    3 Liu HR*, Zhou C, Fan HQ, Tang JJ, Liu LB, Gao XH, Wang QA, Liu WK. Novel Potent and Selective Acetylcholinesterase Inhibitors as Potential Drugs for the Treatment of Alzheimer’s Disease: Synthesis, Pharmacological Evaluation, and Molecular Modeling of Amino-Alkyl-Substituted Fluoro-Chalcones Derivatives.Chem Biol Drug Des, 2015, 86(4):517–522.
    4 Liu HR*, Liu XJ, Fan HQ, Tang JJ, Gao XH, Liu WK.Design, synthesis and pharmacological evaluation of chalcone　derivatives as acetylcholinesterase inhibitors. Bioorgan  Med  Chem  22 (2014) 6124–6133.
    5 Liu HR, Huang XQ, Lou DH, Liu XJ, Liu WK, Wang QA*. Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. Bioorgan  Med  Chem  Lett 24 (2014) 4749–4753.
    6 Liu HR*, Liu Y, Li YL, Qi MY, Liu WK. Synthesis and biological activity of nitric oxide-releasing derivatives of ferulic acid as potential agents for the treatment of chronic kidney diseases. Med Chem. 2013;9(6):875-880.
    7 Gao XH， Zhou C，Liu HR*，Liu LB，Tang JJ，Xia XH*.Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group.J Enzyme Inhib Med Chem. 2016 Nov 1:1-7. [Epub ahead of print]
    8 Duan KK, Liu HR, Fan HQ, Zhang J, Wang QA*. Synthesis and anticholinesterase inhibitory activity of Mannich base derivatives of flavonoids.   J  Chem  Res, 2014, 38：443–446.
   

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